聯絡電話 Contact Phone
(886)2-2905-2474
劉維民
個人網站 Lab Website
副教授 Associate Professor
Wei-Min Liu
- 電子信箱 Email Address
133797@mail.fju.edu.tw
研究領域 Research fields
- Development of Fluorescent Toolboxes for proteins of interest.
- Development of Molecular Modulators that can modulate the protein aggregation process.
- Development of new synthetic methodologies for the synthesis of Bioactive Bio-molecules.
經歷 Experiences
學歷 Education
2013 Ph.D. Leiden University, The Netherland (荷蘭萊頓大學 博士)
2007 M.A. National Taiwan University (國立臺灣大學 碩士)
2005 B.A. National Taiwan Normal University (國立臺灣師範大學 學士)
經歷 Work and Research Experiece
Aug. 2023 – Present Director, Academic Exchange Center & EU Center (國際學術交流中心暨歐盟中心 主任)
Aug. 2022 – Present Associate Professor, Fu Jen Catholic University (天主教輔仁大學 副教授)
Feb. 2016 – Jul. 2022 Assistant Professor, Fu Jen Catholic University (天主教輔仁大學 助理教授)
May 2015 – Dec. 2015 Researcher, Sunny Pharmtech., Taiwan (祥翊製藥股份有限公司 研究員)
Jan. 2014 – Jan. 2015 Postdoctoral Researcher, Oxford University, U.K. (英國牛津大學 博士後研究員)
獲獎經歷 Honors & Awards
- 2023 NSCT Special Outstanding Talent Award (國科會補助大專校院獎勵特殊優秀人才)
- 2022 Fu Jen Catholic University 111 Academic Year – Teaching Excellence Award
- 2022 Fu Jen Catholic University Recruiting and Retaining Outstanding Talent Award
- 2008 48th National and Private High School Science Fair Excellent Work from Ministry of Education R. O. C.
- 2007 Outstanding Graduate Research Poster Award from Department of Chemistry, NTU (awarded to top 20% research excellence)
- 2007 Excellent Oral Presentation Award from Department of Chemistry, NTU (awarded for clarity of oral presentation)
- 2006 Excellent Organic Graduate Research Poster Award from Chinese Chemical Society (awarded to top 15% research posters nationwide)
演講 Presentation
Selected Oral/Post Presentations
Nov. 2019 Oral Presentation at MOST Chemistry Promotion Center Organic-subgroup anniversary meeting, Sun Yat-sen University
May 2018 Oral Presentation at Leiden University
Nov. 2014 Oral Presentation at National Cheng University
Sep. 2013 Oral Presentation at Opening of the Paramagnetic NMR Facility Leiden
Oct. 2012 Oral Presentation at 2012 Annual Meeting of NWO-Chemical Sciences study group meeting for Organic Chemistry & Synthesis
Apr. 2011 Oral Presentation at National Wageningen symposium
Dec. 2006 Poster at 2006 Annual Meeting of Chinese Chemical Society
研究成果 Research Results
期刊發表 Publications (As a PI)
1. Ai-Ci Chan, Pei-Ya Shan, Men-Hsin Wu, Pin-Han Lin, Chang-Shun Tsai, Chia-Chien Hsu, Ting-Hsiang Chiu, Ting-Wei Hsu, Yi-Cheun Yeh, Yun-Ju Lai*, Wei-Min Liu* and Ling-Hsien Tu*. “Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity” Chem. Commun. 2023, 59, 10660-10663.
2. Hui-Hsuan Yu, Pin-Han Lin, Zhao-Bin Chen, Zhi-Wen Chen, Yen-Jen Chen, Wei-Min Liu*, and Ching-Ping Liu*. “Molecular Engineering to Boost the Photo-Oxidase Activity of Molecular Rotors in Colorimetric Sensing of Temperatures” Chem. Eur. J. 2023, 29, e202301591.
3. Han-Yu Chen, Chung-Siang Teng, Pin-Han Lin, Ching-Ping Liu, Wei-Min Liu*, and Li-Kang Chu*. “Noncovalent Association Thermodynamics of Turn-On Fluorescent Probes with Human Serum Albumin: Dual-Concentration Ratio Method” ChemBioChem. 2023, 24, e202300370.
4. Yu-Hsuan Wu, Yu-Pei Chang, Chia-Chien Hsu, Yi-Lun Chen, Pin-Han Lin, Ting-Wei Hsu, Wei-Min Liu, Yun-Ju Lai, Mei-Yi Liao*, and Ling-Hsien Tu*. “Synthesis of Fe3O4-Chlorophyllin Nanoparticles for Preventing Amyloid Formation by Human Calcitonin” ACS Appl. Nano Mater. 2023, 6, 12598-12608.
5. Ya-Chu Ku, Pin-Han Lin, Chung-Yu Huang, Chia-Wei Lee, Chien-Hung Yu, Shih-Cheng Chen*, and Wei-Min Liu*. “An iminocoumarin based covalent-assembly red-emitting fluorescent probe for detection of β-galactosidase activity in ovarian cancer cells” Dyes Pigm. 2023, 210, 111004.
6. Pin-Han Lin, Chang-Shun Tsai, Chia-Chien Hsu, I-Ren Lee, Yu-Xin Shen, Hsiu-Fang Fan, Yun-Wen Chen*, Ling-Hsien Tu*, and Wei-Min Liu*. “An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide” Talanta 2023, 254, 124130.
7. Shih-Ting Ma, Chia-Wei Lee, and Wei-Min Liu*. “Synthesis of 4-thiol-furanosidic uronate via hydrothiolation reaction” RSC Adv. 2021, 11, 18409.
8. Kuan-Hsuan Su, Chin-Teng Wu, Shang-Wei Lin, Seiji Mori, Wei-Min Liu*, and Hsiao-Ching Yang*. “Calculation of CYP450 protein–ligand binding and dissociation free energy paths” J. Chem. Phys. 2021, 155, 025101.
9. Wei-Ling Chen, Shih-Ting Ma, Yun-Wen Chen, Yen-Cheng Chao, Ai-Ci Chan, Ling-Hsien Tu*, and Wei-Min Liu*. “A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design” Biochemistry 2020, 59, 1482–1492.
10. Ai-Ci Chan, Pin-Han Lin, Wei-Min Liu*, and Ling-Hsien Tu*. “Fluorescence Chemicals to Detect Amyloidogenic Protein Aggregation” 化學 2020, 78, 35-47.
11. Qing Miao, Wei-Min Liu, Thomas Kock, Anneloes Blok, Monika Timmer, Mark Overhand, and Marcellus Ubbink*. “A Double-Armed, Hydrophilic Transition Metal Complex as a Paramagnetic NMR Probe” Angew. Chem. 2019, 131, 13227-13234.
12. Yin Yao Dong, Hua Wang, Ashley C.W. Pike, Stephen A. Cochrane, Sadra Hamedzadeh, Filip J. Wyszynski, Simon R. Bushell, Sylvain F. Royer, David A. Widdick, Andaleeb Sajid, Helena I. Boshoff, Yumi Park, Ricardo Lucas, Wei-Min Liu, Seung Seo Lee, Takuya Machida, Leanne Minall, Shahid Mehmood, Katsiaryna Belaya, Wei-Wei Liu, Amy Chu, Leela Shrestha, Shubhashish M.M. Mukhopadhyay, Claire Strain-Damerell, Rod Chalk, Nicola A. Burgess-Brown, Mervyn J. Bibb, Clifton E. Barry III, Carol V. Robinson, David Beeson, Benjamin G. Davis*, and Elisabeth P. Carpenter*. “Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design” Cell 2018, 175, 1045-1058.
13. Witold Andrałojć, Yoshitaka Hiruma, Wei-Min Liu, Enrico Ravera, Masaki Nojiri, Giacomo Parigi, Claudio Luchinat, and Marcellus Ubbink*. “Identification of productive and futile encounters in an electron transfer protein complex” Proc. Natl. Acad. Sci. U. S. A. 2017, 114, E1840-1847.
14. Jesika Schilder, Wei-Min Liu*, Pravin Kumar, Mark Overhand, Martina Huberb, and Marcellus Ubbink*. “Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement” Phys. Chem. Chem. Phys. 2016, 18, 5729-5742.
期刊發表 (As a student/postdoc)
1. Simon P. Skinner, Wei-Min Liu, Yoshitaka Hiruma, Monika Timmer, Anneloes Blok, Mathias A. S. Hass, and Marcellus Ubbink*. “Delicate conformational balance of the redox enzyme cytochrome P450cam” Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 9022-9027.
2. Mathias A. S. Hass, Wei-Min Liu, Roman V. Agafonov, Renee Otten, Lien A. Phung, Jesika T. Schilder, Dorothee Kern, and Marcellus Ubbink*. “A minor conformation of a lanthanide tag on adenylate kinase characterized by paramagnetic relaxation dispersion NMR spectroscopy” J. Biomol. NMR 2015, 61, 123-136.
3. Aldo R. Camacho-Zarco, Francesca Munari, Melanie Wegstroth, Wei-Min Liu, Marcellus Ubbink, Stefan Becker, and Markus Zweckstetter*. “Multiple Paramagnetic Effects through a Tagged Reporter Protein” Angew. Chem. Int. Ed. 2014, 54, 336-339.
4. Wei-Min Liu, Mark Overhand, and Marcellus Ubbink*. “The application of paramagnetic lanthanoid ions in NMR spectroscopy on proteins” Coord. Chem. Rev. 2014, 273, 2-12.
5. Wei-Min Liu, Simon P. Skinner, Monika Timmer, Anneloes Blok, Mathias A. S. Hass, Dmitri V. Filippov, Mark Overhand, and Marcellus Ubbink*. “A Two-Armed Lanthanoid-Chelating Paramagnetic NMR Probe Linked to Proteins via Thioether Linkages” Chem. Eur. J. 2014, 20, 6256-6258.
6. Yoshitaka Hiruma, Mathias A.S. Hass, Yuki Kikui, Wei-Min Liu, Betül Ölmez, Simon P. Skinner, Anneloes Blok, Alexander Kloosterman, Hiroyasu Koteishi, Frank Löhr, Harald Schwalbe, Masaki Nojiri, and Marcellus Ubbink*. “The Structure of the Cytochrome P450cam–Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography” J. Mol. Biol. 2013, 425, 4353-4365.
7. Jia-Ying Guan, Peter H. J. Keizers, Wei-Min Liu, Frank Löhr, Simon P. Skinner, Edwin A. Heeneman, Harald Schwalbe, Marcellus Ubbink*, and Gregg Siegal*. “Small-Molecule Binding Sites on Proteins Established by Paramagnetic NMR Spectroscopy” J. Am. Chem. Soc. 2013, 135, 5859-5868.
8. Wei-Min Liu, Peter H. J. Keizers, Mathias A. S. Hass, Anneloes Blok, Monika Timmer, Alexi J. C. Sarris, Mark Overhand, and Marcellus Ubbink*. “A pH-Sensitive, Colorful, Lanthanide-Chelating Paramagnetic NMR Probe” J. Am. Chem. Soc. 2012, 134, 17306-17313.
9. Soumyasri Dasgupta, Xiaoyu Hu, Peter H. J. Keizers, Wei-Min Liu, Claudio Luchinat, Malini Nagulapalli, Mark Overhand, Giacomo Parigi, Luca Sgheri, and Marcellus Ubbink*. “Narrowing the conformational space sampled by two-domain proteins with paramagnetic probes in both domains” J. Biomol. NMR 2011, 51, 253-263.
著作 Book Chapter
1. Ru-Yi Youh, Po-Yen Chen, Yen-Cheng Chao, Di-Hua Luo, Hao-Hsiang Chang, Yu-Ling Chang, Wei-Min Liu*, and Dean Chou*. Chapter 9: Biomarkers and Applications in Alzheimer’s Disease. “Frontiers in Nanobiotechnology Vol. 1, Advances in Biosensing Technology for Medical Diagnosis” Benthem Book.
實驗室介紹 Lab introduction
介紹 Introduction
WML Lab’s research focuses on developing new synthetic methods, designing prodrugs for neurodegenerative diseases, and designing fluorescent probes for amyloid proteins.
WML 實驗室目前著重於開發新穎的合成方法、設計神經退行性疾病的前導藥物，以及設計針對類澱粉蛋白的螢光探針。
成員 Lab Members
Ph.D. Students
Lavanya Chandraseka
Anibea Barbara Zenabu
Master Student
張祐誠
Undergraduate Students
謝昀真
Former Members
許少宣 (MS)
馬詩婷 (MS)
趙彥成 (MS)
李嘉瑋 (MS)
羅睿銘 (MS)
陳衍禎 (MS)
林品菡 (MS)
黃中昱 (BS)
翁瑋翎 (BS)
陳沂禎 (BS)
潘柏瑄 (BS)
活動 Lab Activities
Contact us
Graduate Student
We invite talented college graduates with backgrounds in organic chemistry, physical chemistry, and analytical chemistry to join our team at Fu Jen Catholic University to pursue their academic goals as Ph.D. students.
You can find detailed information on the Fu Jen Catholic University graduate program website or reach out to us via email for further inquiries.
Visiting Graduate Student
Joint graduate students are also welcome to work in our group at Fu Jen Catholic University. Students who are interested in this program can send an email to us to further discuss education plans in detail.
