許哲生老師

成員介紹

Member Introduction

師資陣容

獲獎經歷

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研究領域

  • Organic Synthetic Methodologies
  • Natural Product Synthesis
  • 有機合成方法學開發
  • 天然物合成

「有機合成」實驗室

隨著人口的增加而快速地減少自然資源,其影響了科學、工業、醫藥等發展的進步,進而可能開始侷限人類的生活品質。有機化學合成為基礎科學,其範圍影響工業及醫藥等領域的發展。在自然資源逐漸限縮下,化學家開始朝向永續能源技術的發展,開發催化反應。同時尋找新技術來替代或是優化現有的科技,也吸引化學家探索的目光,發展新穎合成方法學。而上述兩種研究領域同時推動以高效能的方式,來建構高價值之複雜分子之研究。

目前實驗室以研究高氧化價碘試劑作為研究方向之起點,尋找此高價碘試劑之反應性應用於催化反應及新穎方法學開發。最後希望結合上述兩部分研究成果,應用在複雜分子結構之合成。

圖片介紹

Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus.

學術著作

  1. Chun-Lin Chen, Tian-Sih Huang, Po-Hsiang Chang, Che-Sheng Hsu*. Iodide-umpolung catalytic system for nontraditional amide coupling from
    nitroalkanes and amines. Org. Biomol. Chem., 2024, 22, 2780–2790.
  2. Arun K. Ghosh,* Amartyo J. Basu, Che-Sheng Hsu, Monika Yadav. Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of α-Hydroxy Amides. Chem. Eur. J. 2022, 28, e202200941.
  3. Che-Sheng Hsu,+ Carlos R. Gonçalves,+ Veronica Tona, Amandine Pons, Marcel Kaiser and Nuno Maulide.* Leveraging Electron-Deficient Iminium Intermediates in a General Synthesis of Valuable Amines. Angew. Chem. Int. Ed. 2022, 61, e202115435. (+ – these authors contributed equally)
  4. Arun K. Ghosh* and Che-Sheng Hsu. Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest. J. Org. Chem. 2021, 86, 6351-6360. (front cover artwork)
  5. Che-Sheng Hsu and Jim-Min Fang.* Synthesis of (+)-Antroquinonol and Analogues by Using Enantioselective Michael Reactions of Benzoquinone Monoketals. Eur. J. Org. Chem. 2016, 3809-3816.
  6. Che-Sheng Hsu, Ho-Hsuan Chou and Jim-Min Fang.* A short synthesis of (±)-antroquinonol in an unusual scaffold of 4-hydroxy-2-cyclohexenone. Org. Biomol. Chem. 2015, 13, 5510–5519.
  7. Bor-Cherng Hong,* Che-Sheng Hsu and Gene-Hsiang Lee. Enantioselective total synthesis of (+)-galbulin via organocatalytic domino Michael–Michael–aldol condensation.  Chem. Comm. 2012, 48, 2357–2456. (front cover artwork)
  8. Bor-Cherng Hong,* Nitin S. Dange, Che-Sheng Hsu, and Ju-Hsiou Liao. Dynamic Kinetic Asymmetric Synthesis of Five Contiguous Stereogenic Centers by Sequential Organocatalytic Stetter and Michael−Aldol Reaction: Enantioselective Synthesis of Fully Substituted Cyclopentanols Bearing a Quaternary Stereocenter. Org. Lett. 2011, 13, 1278-1281.
  9. Bor-Cherng Hong,* Nitin S. Dange, Che-Sheng Hsu, and Ju-Hsiou Liao. Sequential Organocatalytic Stetter and Michael-Aldol Condensation Reaction: Asymmetric Synthesis of Fully Substituted Cyclopentenes via a [1 + 2 + 2] Annulation Strategy. Org. Lett. 2010, 12, 4812–4815.

研討會論文

專利或專書

  1. Nuno Maulide, Daniel Kaiser, Veronica Tona, Carlos Goncalves, Saad Shaaban, and Che-Sheng Hsu. Use of substituted aminals in acid-promoted, metal-free hydroaminoalkylations of alkenes and alkynes. From PCT/EP2019/062867.
  2. Jim-Min Fang and Che-Sheng Hsu. Compositions and methods for the preparation of 4-oxy-2-cyclohexeneone and 6-oxy-2cyclohexeneone compounds. From PCT Int. Appl. (2016), WO 2016011130 A1 Jan 21, 2016.

環境介紹

Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus.

Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. Cras dapibus.

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