成員介紹

Member Introduction

師資陣容

楊小青

特聘教授

Hsiao-Ching Yang

專長

  • 物理化學
  • 理論計算科學

詳細了解

楊小青老師個人網頁

學歷

期間學校系所學位
2004國立中山大學化學系化學系博士
1999國立中山大學化學系化學系 學士

經歷

期間單位部門職稱
2023.02～輔仁大學化學系特聘教授
2020.08～2024.02輔仁大學研發處研發長
2019.02～2023.02輔仁大學化學系教授
2018.08～2020.07輔仁大學研發處研發管理中心主任
2012.02～2019.01輔仁大學化學系副教授
2006~2012.01輔仁大學化學系助理教授
2006美國俄亥俄州立大學藥學院博士後研究員
2004-2005國立台灣大學化學所博士後研究員

研究成果

期刊論文

獲獎經歷研究領域期刊論文實驗室介紹

獲獎經歷

  • 日本JST櫻花科學計劃（2018年）
  • 台灣科技部吳大猷紀念獎（2016年）
  • 輔仁大學傑出研究獎（2015年）
  • 第62屆日本高分子學會亞洲卓越獎（2013年）
  • Science Editor’s Choice, 2011, 333, 500. C&EN Concentrates, 2011, 89 (30).

研究領域

  • Main field: PHYSICAL CHEMISTRY, Computational Chemical Dynamics of Complexed Systems
  • Developing fields: Mapping of enzymatic process and kinetics by fluorescence lifetime methods and X-ray/neutron scattering imaging.
  • Current research interests: Development and application of advanced computational chemical dynamics methods for X-ray/neutron scattering data analysis of biomolecules in solution.

學術著作

2011-present

  1. “Light Induced Proton Coupled Charge Transfer Triggers Counterion Directional Translocation.” Kai-Hsin Chang, Yu-Hsuan Yang, Kuan-Hsuan Su, Yi Chen, Ta-Chun Lin, Jian-Liang Li, Zong-Ying Liu, Jing-Han Shi, Tzu-Fang Wang, Yi-Tyng Chang, Alexander P. Demchenko, Hsiao-Ching Yang*, Pi-Tai Chou*, Angew. Chem. Int. Ed. 2024. IF: 16.6, Chemistry, Multidisciplinary, Q1, rank: 13/178.

  2. “Arrayed Pt Single Atoms via Phosphotungstic Acids Intercalated in Silicate Nanochannels for Efficient Hydrogen Evolution Reactions.” Je-Wei Chang, Kuan-Hsuan Su, Chih-Wen Pao, Jin-Jia Tsai, Chun-Jen Su, Jeng-Lung Chen, Lian-Ming Lyu, Chun-Hong Kuo, An-Chung Su, Hsiao-Ching Yang*, Ying-Huang Lai*, and U-Ser Jeng*, ACS Nano, 2024, 18 (2), 1611-1620. IF: 18.027, Chemsitry, Multidisciplinary, Q1, rank: 12/178.

  3. “A green and ultrafast one-pot mechanochemical approach for efficient biocatalyst encap-sulation in MOFs: insights from experiments and computation.” Phuc Khanh Lam, Trung Hieu Vo, Jing-Hui Chen, Shang-Wei Lin, Chiao-Ling Kuo, Jian-Jie Liao, Kuan-Yu Chen, Sen-Ruo Huang, Dong Li, Yun-Hsiang Chang, Hsuan-Yi Chen, Haw-Ting Hsieh, Yu-An Hsu, Heng-Kwong Tsao, Hsiao-Ching Yang* and Fa-Kuen Shieh*, J. Mater. Chem. A, 2023. IF: 11.9, Chemsitry, Physical, Q1, rank: 24/161.

  4. “An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation.”Nadendla EswarKumar, Cheng-Han Yang, Sunilkumar Tewary, Wen-Hsin Peng, Guang-Chao Chen, Yi-Qi Yeh, Hsiao-Ching Yang*, and Meng-Chiao Ho*, Structure 2023. 2023. IF:5.7, Biophysic, Q1, rank: 10/70.

  5. “Long-range hydrogen-bond relay catalyses the excited-state proton transfer reaction.” Kai-Hsin Chang, Yu-Chiang Peng, Kuan-Hsuan Su, Yi-Hsien Lin, Jiun-Chi Liu, Ying-Hsuan Liu, Chao-Hsien Hsu, Hsiao-Ching Yang* and Pi-Tai Chou*, Chem. Sci., 2023,14, 7237-7247. IF:  8.4, Chemistry – Multidisciplinary, Q1, rank: 26/230.

  6. “Calculation of CYP450 Protein Ligand Binding and Dissociation Free Energy Paths.” Kuan-Hsuan Su, Chin-Teng Wu, Shang-Wei Lin, Seiji Mori, Wei-Min Liu*, and Hsiao-Ching Yang*, J. Chem. Phys. 2021, 155(2), 025101. IF: 3.488, Physics, atomic,  molecular & chemical, Q1, rank: 9/37.

  7. “Temperature Effect on Water Dynamics in Tetramer Phosphofructokinase Matrix and the Super-Arrhenius Respiration Rate” Hsiao-Ching Yang*, Yung-Chi Ge, Kuan-Hsuan Su, Chia-Cheng Chang, King-Chuen Lin, Vincenzo Aquilanti, and Toshio Kasai*, Sci. Rep. 2021, 11(1), 1-14. IF: 3.998, Multidisciplinary Sciences, Q1, rank: 17/71.

  8. “Molecular Dynamics Simulation Combined with small-angle X-ray/Neutron Scattering Defining Solution State Protein Structures.”Shang-Wei Lin, Kuan-Hsuan Su, Yi-Qi Yeh, U-Ser Jeng, Chun-Ming Wu, Hsiao-Ching Yang*. J Chin Chem Soc., 2020, 20(9), 403-408. This paper is special issue dedicated to Prof. Chung‐Yuan Mou. IF:1.554, Chemistry, Multidisciplinary, Q3, rank: 120/177.

  9. “Probing Interactions between Metal–Organic Frameworks and Freestanding Enzymes in a Hollow Structure.” Sheng-Yu Chen, Wei-Shang Lo, Yi-Da Huang, Xiaomeng Si, Fu-Siang Liao, Shang-Wei Lin, Benjamin P. Williams, Ting-Qian Sun, Hao-Wei Lin, Yuanyuan An, Tu Sun, Yanhang Ma, Hsiao-Ching Yang*, Lien-Yang Chou*, Fa-Kuen Shieh*, and Chia-Kuang Tsung*, Nano Lett., 2020, 20(9), 6630–6635. IF: 11.238, Physics Applied, Q1, rank: 11/155, top 7%.

  10. “Could Chemical Reaction at the Molecular Level Show Distinction between Two Liquid-Water States? Study of the Excited-State Water-Catalyzed Proton Transfer Reaction Provides a Clue” Yu-Hsuan Cheng, Hsiao-Ching Yang*, and Pi-Tai Chou*, J. Phys. Chem. Lett., 2020, 11(21), 9468-9475. IF: 6.710, Chemistry Physical, Q1, rank: 3/37,top 8%. 

  11. “[1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, inhibits glutamate release in rat cerebrocortical nerve terminals by suppressing the P/Q-type Ca2+ channels and Ca2+/calmodulin/protein kinase A pathway.” Cheng-Wei Lu, Tzu-Yu Lin, Hsiao-Ching Yang, Chi-Feng Hung, Jing-Ru Weng, Der-Chen Chang, Su-Jane Wang*. Neurochemistry International, 2020, 140: 104845. IF: 3.811, Neuro Science, Q2, rank: 95/272.

  12.  “Substrate Channeling of Prostaglandin H2 on the Stereochemical Control of a Cascade Cyclization Route” Hsiao-Ching Yang*, Yung-Chi Ge, Cheng-Han Yang , and Wei-Chih Chao, ACS catalysis 2018, 8, 2534-2545. IF: 12.350, Chemistry Physical, Q1, rank: 12/159, top 7%.

  13. “Unveiling the water-associated conformational mobility in the active site of ascorbate peroxidase”Wei-Chih Chao, Li-Ju Lin, Jyh-Feng Lu*, Jinn-Shyan Wang*, Tzu-Chieh Lin, Yi-Han Chen, Yi-Ting Chen, Hsiao-Ching Yang, Pi-Tai Chou.BBA-General Subjects 2018, 1862 (3), 451-459. IF:3.422, Biophysics, Q2, rank: 19/71.

  14.  “Homology Modeling and Molecular Dynamics Simulation Combined with X-ray Solution Scattering Defining Protein Structures of Thromboxane and Prostacyclin Synthases” Hsiao-Ching Yang*, Cheng-Han Yang, Ming Yi Huang, Jyh-Feng Lu, Jinn-Shyan Wang, Yi-Qi Yeh, U-Ser Jeng, J. Phys. Chem. B 2017, 121(50), 11229-11240. IF: 3.051, Chemistry Physical, Q2, rank: 76/159.

  15. “The In Situ Tryptophan Analogue Probes the Conformational Dynamics in Asparaginase Isozymes” Wei-Chih Chao, Jiun-Yi Shen, Cheng-Han Yang, Yi-Kang Lan, Jui-Hung Yuan, Li-Ju Lin, Hsiao-Ching Yang*, Jyh-Feng Lu, Jinn-Shyan Wang, Kevin Wee, You-Hua Chen, Pi-Tai*, Biophysical Journal 2016, 110(8), 1732–1743. IF: 3.854, Biophysics, Q1, rank: 15/71.

  16. “Probing the polarity and water environment at the protein-peptide binding interface using tryptophan analogues”Yi-Ting Chen, Wei-Chih Chao, Hsiou-Ting Kuo, Jiun-Yi Shen, I-Han Chen, Hsiao-Ching Yang, Jinn-Shyan Wang, Jyh-Feng Lu, Richar d P Cheng*, Pi-Tai Chou*.Biophysics Reports 2016, 7, 113-118. IF: 4.105, Cell Biology, Q2, rank: 77/195.

  17. “Probing Water Environment of Trp59 in Ribonuclease T1: Insight of the Structure−Water Network Relationship” Wei-Chih Chao, Jiun-Yi Shen, Jyh-Feng Lu,*,Jinn-Shyan Wang,*, Hsiao-Ching Yang*, Kevin Wee, Li-Ju Lin, Yi-Ching Kuo, Cheng-Han Yang, Shih-Hui Weng, Huai-Ching Huang, You-Hua Chen, and Pi-Tai Chou*,  J. Phys. Chem. B ,2015, 119(6), 2157.
    IF: 3.051, Chemistry Physical, Q2, rank: 76/159.

  18. “Probing Water Micro-solvation in Proteins by Water Catalyzed Proton-Transfer Tautomerism.” Jiun-Yi Shen, Wei-Chih Chao, Chun Liu, Hsiao-An Pan, Hsiao-Ching Yang*, Chi-Lin Chen, Yi-Kang Lan, Li-Ju Lin, Jinn-Shyan Wang, Jyh-Feng Lu, Steven Chun-Wei Chou, Kuo-Chun Tang and Pi-Tai Chou* Nature Communication 2013, 4, 2611. IF:12.121, Multidisciplinary Sciences, Q1, rank: 6/71, top 8%.

  19. “On the Stereoselectivity of Ring-Opening Metathesis Polymerization (ROMP) of N-Arylpyrrolidine-Fused Cyclobutenes with Molybdenum– and Ruthenium–Alkylidene Catalyst” Nai-Ti, Lin, Yuan-Zhen, Ke, Kamani Satyanarayana, Shou-Ling Huang, Yi-Kang Lan, Hsiao-Ching Yang, and Tien-Yau Luh* Macromolecules 2013, 46, 18, 7173–7179. IF:5.918, polymer science, Q1, rank:7/89.

  20. “Probing Ligand Binding to Thromboxane Synthase” Wei-Chih Chao, Jyh-Feng Lu, Jinn-Shyan Wang,* Hsiao-Ching Yang, Tai-An Pan, Steven Chun-Wei Chou, Lee-Ho Wang, and Pi-Tai Chou Biochemistry 2013, 52(6), 1113. IF:2.865, Biochemistry & Molecular Biology, Q3, rank: 169/297.

  21. “Vitamin E Facilitates the Inactivation of the Kinase Akt by the Phosphatase PHLPP1”Po-Hsien Huang, Hsiao-Ching Chung, Chih-Chien Chou, Huiling Wang, Su-Lin Lee, Hsiao-Ching Yang, Hao-Chieh Chiu, Naval Kapuriya,Dasheng Wang, Samuel K. Kulp, and Ching-Shih Chen,* Science Signaling (AAAS) 2013, 6 (267), ra19. IF:6.378, Biochemistry & Molecular Biology, Q1, rank: 39/297.

  22. “Ambipolar carrier transport properties in a built-indonor–acceptor discogen” Li-Yin Chen, Fei-Hsiung Chien*, Yen-Wei Liu, Wenjun Zheng, Cheng-Yan Chiang, Chia-Yi Hwang, Chi-Wi Ong, Yi-Kang Lan, Hsiao Ching Yang, Organic Electronics 2013, 14 (8), 2065-2070. IF:3.310, Physics Applied, Q2, rank: 41/155.

  23. “Identification of Kazinol Q, a Natural Productfrom Formosan Plants, as an Inhibitor of DNAMethyltransferase” Jing-Ru Weng*, I-Lu Lai, Hsiao-Ching Yang, Chun-Nan Lin, and Li-Yuan Bai PHYTOTHERAPY RESEARCH Phytother. Res. 2013, 28 (1), 49-54. IF:4.087, Chemistry Medicinal, Q1, rank: 15/61.

  24. “Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells”Jian-Ying Chuang, Susan A Wang, Wu-Bin Yang, Hsiao-Ching Yang, Chiung-Yu Hung, Tsung-Ping Su, Wen-Cheng Chang, Jan-Jong Hung*.Oncogene 2012, 31, 4946-4959. IF:7.971, Genetics & Heredity, Q1, rank: 14/178, top:7%.

  25. “Probing the Interaction between Prostacyclin Synthase and Prostaglandin H2 Analogues or Inhibitors via Combination of Resonance Raman Spectroscopy and Molecular Dynamics Simulation Approaches” Wei-Chih Chao, Jyh-Feng Lu, Jinn-Shyan Wang, Hsiao-Ching Yang* ,Hsiao-Hui Chen, Yi-Kang Lan, Ya-Chien Yu, Pi-Tai Chou*, and Lee-Ho Wang J. Am. Chem. Soc. 2011, 133 (46), 18870–18879. IF:14.612, Chemistry, Multidisciplinary, Q1, rank: 13/177, top:7%.

  26. “Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator” Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro and Ching-Shih Chen,* Journal of Biological Chemistry 2011, 286 (45), 39247-39258. IF:4.106, Biochemistry & Molecular Biology, Q2, rank: 87/297. 

  27. 本篇論文獲選Science Editors’Choice highlight [Science, 2011, 333, 500].
    “Carbene Rotamer Switching Explains the Reverse Trans Effect in Forming the Grubbs Second-Generation Olefin Metathesis Catalyst” Hsiao-Ching Yang    * ,Yen-Chin Huang, Yikang Lan, Tien-Yau Luh, Yan Zhao and Donald G. Truhlar* Organometallics 2011, 30 (15), 4196–4200. IF:3.804, Chemistry, Inorganic & Nuclear, Q1, rank: 6/45,top 13%.

  28. “Chiral amplification in one-dimensional helical nanostructures self-organized from phenylethynyl thiophene with elaborated long-chain dicarboxamides.” Chun-Hsian Li, Kai-Chi Chang, Chia-Chen Tsou, Yikang Lan, Hsiao-Ching Yang*, and Shih-Sheng Sun* J. Org. Chem. 2011, 76, 14, 5524–5530 IF:4.335, CHEMISTRY, ORGANIC, Q1, rank: 9/57. 

  29. “Enforced liquid crystalline properties of dibenzo [a, c] phenazine dimer and self assembly” Mei-Chun Tzeng,a Su-Chih Liao, Tsu-Hsin Chang, Shih-Chi Yang, Min-Wei Weng, Hsiao-Ching Yang, Michael Y. Chiang, Zhang Kai, Jishan Wuc and Chi Wi Ong* Journal of Materials Chemistry 2011, 21 (6), 1704-1712.

專長領域

Nam eget dui. Etiam rhoncus. Maecenas tempus, tellus eget condimentum rhoncus.

* 物理有機化學
* 多尺度電腦模擬技術
* 小角寬角X光/中子散射技術結合多尺度動力學模擬技術

環境介紹

楊小青教授的研究團隊，致力於物理化學與計算化學的前沿，運用現代計算和理論分析以及精心設計的實驗，深入探究從分子到納米級的化學物理過程。我們專注於解析電環式有機反應的機理，以及分子間相互作用如何影響複雜結構和分子識別，推動物理化學和生物物理學的發展。我們積極應用X射線/中子散射技術於生物分子研究，尤其專注於利用計算化學動力學創新方法進行SAXS數據分析，提供對單分散系統、瞬態複合體以及靈活和異質系統結構的深刻理解。我們的研究同時結合SAXS和高分辨率分子動力學模擬，融合生化、生物物理和數值編程技術，並在國際同步輻射設施進行突破性實驗。我們的目標是開拓新的研究途徑，促進科學和應用領域的革新發展。

楊教授領導的研究團隊是一個跨領域的實驗室，我們歡迎充滿動力與熱情的學生（包含本科生及研究生）加入我們的行列。

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