成員介紹

Member Introduction

師資陣容

李慧玲

教授

Hui-Ling, Lee

  • 聯絡電話

    022905-3573 

  • 電子信箱

    076308@mail.fju.edu.tw

專長

  • 生化與環境分析化學
  • 電化學
  • 質譜分析

詳細了解

實驗室網頁

學歷

學校系所學位
輔仁大學化學系博士
高雄醫學院化學系學士

經歷

期間單位部門職稱
2008國家衛生研究院環境衛生與職業醫學組博士後研究
2009.2輔仁大學化學系助理教授
2012.8輔仁大學化學系副教授
2017.8輔仁大學化學系教授
2018.8~2020.7輔仁大學化學系環安衛中心主任
2020.8~2023.7輔仁大學化學系系主任

研究成果

期刊論文

獲獎經歷研究領域期刊論文實驗室介紹

獲獎經歷

  • 1040312 傑出研究獎(102 學年)

  • 1041111 班級導師經營獎

  • 1050107教學成果獎

  • 103年榮獲科技部優秀人才獎勵

  • 104年榮獲科技部優秀人才獎勵

  • 105年榮獲科技部優秀人才獎勵

  • 106年榮獲科技部優秀人才獎勵

  • 107年榮獲科技部優秀人才獎勵

  • 108年榮獲科技部優秀人才獎勵

  • 109年榮獲科技部優秀人才獎勵

  • 1090211傑出研究獎 (107 學年)

  • 1100201~1110131 焯炤講座

研究領域

  • 以高效能液相層析儀串聯質譜分析 (HPLC-MS/MS) 來研究環境污染物 (如砷、二手煙、奈米材料、揮發性有機氣體、PM2.5和PAHs)以及對人體健康危害的生物性指標物如DNA 氧化性傷害研究之8-OHdG (8-oxo-7,8-dihydro-2’-deoxyguanosine)、DNA 甲基化(Global methylation)、脂質過氧化(Lipid peroxidation) 之8-iso-prostaglandin F2α、香煙致癌物NNK 的代謝物種和揮發性有機氣體代謝物種分析。

  • 串聯式四極柱質譜儀與飛行時間質譜儀 (LC-Q-TOF) 研究暴露質體學(Exposomics) 以動物模式和人體暴露於環境污染物下，進行全面性的代謝輪廓譜分析(Metabolite profiling) 和代謝物標靶分析(Metabolite target analysis) 找出新穎的生物性指標物如胺基酸 (Amino acids)、色胺酸代謝物(Tryptophan metabolites)、花生四烯酸代謝物(Arachidonic acid metabolites) 以及全氟碳化合物系列 (Perfluoroalkyl substances, PFAS) 等。

  • 開發新穎材料應用於樣品前處理領域，如金屬有機骨架化合物(Metal–organic frameworks, MOFs)、磁性奈米材料等。

學術著作

  1. Chien‑Yu Lin, Hui‑Ling Lee, Chikang Wang, Fung‑Chang Sung and Ta‑Chen Su, “Positive Association Between Serum Concentration of 4-Tertiary-octylphenol and Oxidation of DNA and Lipid in Adolescents and Young Adults” Exposure and Health, 2024, https://doi.org/10.1007/s12403-024-00628-6 (SCI, impact factor: 6.7, Ranking (Water Resource):7/103 =6.79 % (Q1),5-Year IF: 6.1). Times cited: 0
  2. Yi-Hsuan Hsieh, Wei-Ting Jung, Hui-Ling Lee* ,“Novel vinylene-based covalent organic framework as a promising adsorbent for the rapid extraction of beta-agonists in meat samples”, Analytica Chimica Acta 2023,1272, 341492. https://doi.org/10.1016/j.aca.2023.341492 (通訊作者, SCI, impact factor: 6.2, Ranking (Chemistry, Analytical): 8/86 = 9.30 % (Q1), 5-Year IF: 5.9). Times cited: 0.
  3. Chao-Lin Chung, Tsung-Ting Shih, Hui-Ling Lee* “Development of a novel vinylene-linked covalent organic framework decorated with multi-walled carbon nanotubes for electrochemical detection of tryptophan, uric acid, and 8-hydroxy-2′-deoxyguanosine”, Journal of the Chinese Chemical Society 2023,70 1796-1806. https://doi.org/10.1002/jccs.202300184 (通訊作者, SCI, impact factor: 8, Ranking (Chemistry, Multidisciplinary): 123/178 = 75.42 % (Q3), 5-Year IF: 1.6). Times cited: 0.
  4. Wei-Ting Jung, Yi-Hsuan Hsieh, Yen-Jung Kuo, Yuan-Hsiang Yu, Yen-Hsiang Liu, Kuang-Lieh Lu, Hui-Ling Lee* “Rapid microwave synthesis of MOF microrods: dispersive SPE coupled with UHPLC–MS/MS to determine fluoroquinolones in honey”, Talanta, 2023, 263 124733 (通訊作者, SCI, impact factor: 1, Ranking (Chemistry, Analytical): 9/86 = 10.46 % (Q1), 5-Year IF: 5.4). Times cited: 0.
  5. Chao-Yuan Huang, Wei-Jen Chen, Hui-Ling Lee, Ying-Chin Lin, Ya-Li Huang, Horng-Sheng Shiue, Yeong-Shiau Pu and Yu-Mei Hsueh*, “Possible combined effects of plasma folate levels, global DNA methylation, and blood cadmium concentrations on renal cell carcinoma”, Nutrients 2023, 15, 937. https://doi.org/10.3390/nu15040937 (SCI, impact factor: 5.9, Ranking (Nutrition & Dietetics): 17/88 = 19.31 % (Q1), 5-Year IF: 6.6). Times cited: 0
  6. Chi‑Jung Chung*, Hui‑Ling Lee, Chao‑Hsiang Chang, Chih‑Da Wu, Chiu‑Shong Liu, Mu‑Chi Chung, Hui‑Tsung Hsu, “Determination of potential sources of heavy metals in patients with urothelial carcinoma in central Taiwan: a biomonitoring case–control study”, Environmental Geochemistry and Health 2023, 45, 5401–5414. https://doi.org/10.1007/s10653-023-01481-3 (SCI, impact factor: 4.2, Ranking (Environmental Sciences): 104/274 = 37.95 % (Q2), 5-Year IF: 4.4). Times cited: 1
  7. Chien‑Yu Lin, Hui‑Ling Lee, Ching‑Way Chen, Chikang Wang, Fung‑Chang Sung and Ta‑Chen Su, “The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population” Clinical Epigenetics, 2023, 15:87, (SCI, impact factor: 5.7, Ranking (GENETICS & HEREDITY): 25/171 = 14.62 % (Q1), 5-Year IF: 6.70). Times cited: 0
  8. Chien-Yu Lin, Hui-Ling Lee, Ching-Way Chen, Chikang Wang, Fung-Chang Sung, Ta-Chen Su*, “Global DNA methylation mediates the association between serum perfluorooctane sulfonate and carotid intima-media thickness in young and middle-aged Taiwanese populations”, Ecotoxicology and Environmental Safety 2022, 241, 113782, DOI: https://doi.org/10.1016/j.ecoenv.2022.113782 (SCI, impact factor: 6.8, Ranking (Toxicology): 6/94 = 6.38 % (Q1), 5-Year IF: 6.9). Times cited: 1
  9. Hui‑Tsung Hsu, Hui‑Ling Lee, Hsu‑Hui Cheng, Chao‑Hsiang Chang, Chiu‑Shong Liu, Po‑Jen Hsiao, Han Chang, Chi‑Shun Lien, Mu‑Chi Chung, Chi‑Jung Chung*,”Relationships of multiple metals exposure, global DNA methylation, and urothelial carcinoma in central Taiwan”, Archives of Toxicology 2022, 96, 1893–1903, https://doi.org/10.1007/s00204-022-03260-y (SCI, impact factor: 6.1, Ranking (Toxicology): 7/94 = 7.45 % (Q1), 5-Year IF: 5.7). Times cited: 1
  10. Chien-Yu Lin, Ching-Way Chen, Hui-Ling Lee, Charlene Wu, Chikang Wang, Fung-Chang Sung, Ta-Chen Su*, “Global DNA methylation mediates the association between urine mono-2-ethylhexyl phthalate and serum apoptotic microparticles in a young Taiwanese population”, Science of the Total Environment 2022, 808, 152054, DOI: 1016/j.scitotenv.2021.152054 (SCI, impact factor: 9.8, Ranking (Environmental Sciences): 25/274 = 9.49 % (Q1),5-Year IF: 9.6). Times cited: 4.
  11. Kun‑Chieh Yeh, Chi‑Feng Hung, Hui‑Ling Lee, Ting‑Yang Hsieh, Su‑Jane Wang*,”Soybean Meal Extract Preserves Memory Ability by Increasing Presynaptic Function and Modulating Gut Microbiota in Rats”, Molecular Neurobiology 2022, 59, 1649–1664, (SCI, impact factor: 5.1, Ranking (Neurosciences): 69/272 = 25.36 % (Q2), 5-Year IF: 5.1). Times cited: 2.
  12. Chien-Yu Lin, Hui-Ling Lee, Chikang Wang, Fung-Chang Sung, Ta-Chen Su*, “Association between the total plasma isomers of per- and polyfluoroalkyl substances and erythrograms in young and middle-aged Taiwanese populations”, Ecotoxicology and Environmental safety 2021, 227, 112902, DOI: 1016/j.eco env.2021.112902 (SCI, impact factor: 6.8, Ranking (Toxicology): 6/94 = 6.38 % (Q1), 5-Year IF: 6.9). Times cited: 7.
  13. Hui-Ling Lee*, Chih-Yuan Kang, Yen-Jung Kuo, Shan-Ni Tseng, “Polydopamine and silica nanoparticles magnetic solid phase extraction coupled with liquid chromatography-tandem mass spectrometry to determine phenolic acids and flavonoids in fruit wine”, Journal of Food and Drug Analysis 2021, 29, 391-401, DOI: 10.38212/2224-6614.3359 (通訊作者, SCI, impact factor: 3.6, Ranking (Pharmacology & Pharmacy): 115/277 = 41.52 % (Q2), 5-Year IF: 6.4). Times cited: 0.
  14. Wei-Te Wu, Wei-Ting Jung, Hui-Ling Lee*, “Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles”, Nanotoxicology 2021 15, 577-587, DOI: 10.1080/17435390.2021.1879303 (通訊作者, SCI, impact factor: 5.0, Ranking (Toxicology): 14/94 = 14.89 % (Q1), 5-Year IF: 5.2). Times cited: 8.
  15. Chi-Jung Chung*, Hui-Tsung Hsu, Chao-Hsiang Chang, Sheng-Wei Li, Chiu-Shong Liu, Mu-Chi Chung, Guo-Wei Wu, Wei-Ting Jung, Yen-Jung Kuo, Hui-Ling Lee*, “Relationships among cigarette smoking, urinary biomarkers, and urothelial carcinoma risk: a case-control study”, Environmental Science and Pollution Research 2020, 47, 43177-43185, DOI: 10.1007/s11356-020-10196-2 (通訊作者, SCI, impact factor: 5.8, Ranking (Environmental Science): 67/274 = 24.45 % (Q1), 5-Year IF: 5.4). Times cited: 3.
  16. Chien-Yu Lin, Hui-Ling Lee, Yi-Ting Hwang, Po-Chin Huang, Chikang Wang, Fung-Chang Sung, Charlene Wu, Ta-Chen Su*, “Urinary heavy metals, DNA methylation, and subclinical atherosclerosis”, Ecotoxicology and Environmental Safety 2020, 204, 111039, DOI: 10.1016/j.ecoenv.2020.111039 (SCI, impact factor: 6.8, Ranking (Toxicology): 7/94 = 6.38 % (Q1), 5-Year IF: 6.9). Times cited: 15.
  17. Jen-Han Wu, Hui-Ling Lee*, “Determination of sunset yellow and tartrazine in drinks using screen-printed carbon electrodes modified with reduced graphene oxide and NiBTC frameworks”, Microchemical Journal 2020, 158, 105133, DOI: 10.1016/j.microc.2020.105133 (通訊作者,SCI, impact factor: 4.8, Ranking (Chemistry, Analytical): 17/86 = 19.77 % (Q1), 5-Year IF: 4.5). Times cited: 29.
  18. Chien-Yu Lin, Hui-Ling Lee, Yi-Ting Hwang, Chikang Wang, Chia-Jung Hsieh, Charlene Wu, Fung-Chang Sung, Ta-Chen Sui*, “The association between urine di-(2-ethylhexyl) phthalate metabolites, global DNA methylation, and subclinical atherosclerosis in a young Taiwanese”, Environmental Pollution 2020, 265, 114912, population, DOI: 10.1016/j.envpol.2020.114912 (SCI, impact factor: 8.9, Ranking (Environmental Science): 28/274 = 10.22 % (Q1), 5-Year IF: 9.5). Times cited: 17.
  19. Chien-Yu Lin, Hui-Ling Lee, Wei-Ting Jung, Fung-Chang Sung, Ta-Chen Su.∗, “The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults”, Journal of Hazardous Materials 2020, 396, 122745, DOI: 10.1016/j.jhazmat.2020.122745 (SCI, impact factor: 13.6, Ranking (Environmental Science): 10/274 = 3.65 % (Q1), 5-Year IF: 12.7). Times cited: 6.
  20. Jhih-Sheng Chen, Yi Li, Meng-Jhe Yu, Hui-Ling Lee*, ‘Multiwalled carbon nanotubes /reduced graphene oxide nanocomposite electrode for electroanalytical determination of bisphenol A, 8-hydroxy-2’-deoxyguanosine and hydroquinone in urine”, International Journal of Environmental Analytical Chemistry 2020, 100, 774-788, July 15 2019, DOI: 10.1080/03067319.2019.1640874 (通訊作者, SCI, impact factor: 2.6, Ranking (Chemistry Analytical)): 49/86 = 56.98 % (Q3), 5-Year IF: 2.5). Times cited: 8.
  21. Chien-Yu Lin, Hui-Ling Lee, Yi-Ting Hwang, Ta-Chen Su.∗, “The association between total serum isomers of per- and polyfluoroalkyl substances, lipid profiles, and the DNA oxidative/nitrative stress biomarkers in middle-aged Taiwanese adults”, Environmental Research 2020, 182, 109064, DOI: 10.1016/j.envr es.2019.109064 (SCI, impact factor: 8.3, Ranking (Public, Environmental & Occupational Health): 16/207 = 7.73 % (Q1), 5-Year IF: 8.2). Times cited: 27.
  22. Wei-Te Wu,* Lih-Ann Li, Tsui-Chun Tsou, Shu-Li Wang, Hui-Ling Lee, Tung-Sheng Shih and Saou-Hsing Liou, “Longitudinal follow-up of health effects among workers handling engineered nanomaterials: a panel study”, Environmental Health 2019, 18, 107, DOI: 10.1186/s12940-019-0542-y (SCI, impact factor: 6, Ranking (Public, Environmental & Occupational Health): 32/207 = 15.46 % (Q1), 5-Year IF: 7). Times cited: 15.
  23. Ya-Yun Wang, Tsung-Hsuan Lai, Mei-Feng Chen, Hui-Ling Lee, Pao-Lin Kuo, Ying-Hung Lin* “SEPT14 mutations and teratozoospermia: genetic effects on sperm head morphology and DNA integrity”, Journal of Clinical Medicine 2019, 8, 9, DOI: 10.3390/jcm8091297 (SCI, impact factor: 3.9, Ranking (Medicine, general & internal): 58/167 = 34.73 % (Q2), 5-Year IF: 4.1). Times cited: 13.
  24. Chi‑Jung Chung, Hui‑Ling Lee, Chao‑Hsiang Chang, Han Chang, Chiu‑Shong Liu, Wei‑Ting Jung, Huei‑Ju Liu, Saou‑Hsing Liou, Mu‑Chi Chung, Yu‑Mei Hsueh, “Measurement of urinary arsenic profiles and DNA hypomethylation in a case-control study of urothelial carcinoma”, Archives of Toxicology 2019, 93, 2155–2164, DOI: 10.1007/s00204-019-02500-y (SCI, impact factor: 6.1, Ranking (Toxicology): 7/94 = 7.44 % (Q1), 5-Year IF: 5.7). Times cited: 12.
  25. Chien-Yu Lin, Hui-Ling Lee, Fung-Chang Sung, Ta-Chen Su∗, “Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults”, Environmental Pollution 2018, 239, 493-498, DOI: 10.1016/j.envpol.2018.04.010 (SCI, impact factor: 8.9, Ranking (Environmental Science): 28/274 = 10.22 % (Q1), 5-Year IF: 9.5). Times cited: 7.
  26. Tsung-Ting Shih, Hui-Ling Lee*, Show-Chuen Chen,∗ Chih-Yuan Kang, Ren-Shang Shen, Yi-An Su, “Rapid analysis of traditional Chinese medicine Pinellia ternata by microchip electrophoresis with electrochemical detection” , Journal of Separation Science 2018, 41, 740–746, DOI: 10.1002/jssc.201700901 (通訊作者, SCI, impact factor: 3.1, Ranking (Chemistry Analytical)): 36/86 = 41.86 %(Q2), 5-Year IF: 2.8). Times cited: 20.
  27. Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee*, “Targeted lipidomics profiling of acute arsenic exposure in mice serum by on-line solid-phase extraction stable-isotope dilution liquid chromatography–tandem mass spectrometry”, Archives of Toxicology 2017, 91, 3079-3091, DOI: 1007/s00204-017-1937-6 (通訊作者, SCI, impact factor: 6.1, Ranking (Toxicology): 7/94 = 7.45 % (Q1), 5-Year IF: 5.7). Times cited: 9.
  28. Chia-Chi Ho, Hui-Ling Lee, Chao-Yu Chen, Yueh-Hsia Luo, Ming-Hsien Tsai, Hui-Ti Tsai & Pinpin Lin∗, “Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation”, Nanotoxicology 2017, 11, 360–370, DOI: 1080/17435390.2017.1306129 (SCI, impact factor: 5.0, Ranking (Toxicology): 14/94 = 14.89 % (Q1), 5-Year IF: 5.2). Times cited: 13.
  29. Chien-Yu Lin, Pau-Chung Chen, Chia-Jung Hsieh, Chao-Yu Chen, Anren Hu, Fung-Chang Sung, Hui-Ling Lee∗, Ta-Chen Su∗, “Positive association between urinary concentration of phthalate metabolites and oxidation of DNA and lipid in adolescents and young adults”, Scientific Reports 2017, 7, 44318, DOI: 1038/sr ep44318  (通訊作者, SCI, impact factor: 4.6, Ranking (Multidisciplinary sciences): 22/73 = 30.14 % (Q2), 5-Year IF: 4.9). Times cited: 30.
  30. Saou-Hsing Liou, Wei-Te Wu, Hui-Yi Liao, Chao-Yu Chen, Cheng-Yen Tsai, Wei-Ting Jung, Hui-Ling Lee∗, “Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles”, Journal of Hazardous Materials 2017, 331, 329– 335, DOI: 10.1016/j.jhazmat.2017.02.042 (通訊作者, SCI, impact factor: 13.6, Ranking (Environmental Science): 10/274 = 3.65 % (Q1), 5-Year IF: 12.7). Times cited: 74.
  31. Chi-Jung Chung, Chao-Hsiang Chang, Saou-Hsing Lioue, Chiu-Shong Liu, Huei-Ju Liue, Li-Ching Hsua, Jhih-Sheng Cheng, Hui-Ling Lee*,“ Relationships among DNA hypomethylation, Cd, and Pb exposure and risk of cigarette smoking-related urothelial carcinoma”, Toxicology and Applied Pharmacology 2017, 316, 107–113, DOI: 10.1016/j.taap.2016.12.016 (通訊作者, SCI, impact factor: 3.8, Ranking (Toxicology): 29/94 = 30.85 % (Q2), 5-Year IF: 4.0). Times cited: 15.
  32. Chao-Yu Chen,Yu-Ting Jhou, Hui-Ling Lee*, Yu-Wen Lin,“ Simultaneous, rapid, and sensitive quantification of 8-hydroxy-2′-deoxyguanosine and cotinine in human urine by on-line solid-phase extraction LC-MS/MS: correlation with tobacco exposure biomarkers NNAL”, Analytical and Bioanalytical Chemistry 2016, 408, 6295–6306, DOI: 1007/s00216-016-9741-3 (通訊作者, SCI, impact factor: 4.3, Ranking (Chemistry, Analytical): 20/86 = 23.26 % (Q2), 5-Year IF: 4). Times cited: 22.
  33. Pinpin Lin, Yi-Rong Chen, Chao-Yu Chen, Ya-Ting Chang, Jhih-Sheng Chen, Ming-Hsien Tsai, Cheng-Chin Kuo, Hui-Ling Lee*, “Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis”, Toxicology Research 2016, 5, 1182-1192 , DOI: 10.1039/c6tx00010j (通訊作者, SCI, impact factor: 2.1, Ranking (Toxicology): 76/94 = 80.85 % (Q4), 5-Year IF: 2.9). Times cited: 0.
  34. Saou-Hsing Liou, Yu-Cheng Chen, Hui-Yi Liao, Chien-Jen Wang, Jhih-Sheng Chen, Hui-Ling Lee*, “Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers”, Biomarkers 2016, 21, 600-606, DOI: 10.3109/1354750X.2016.1160432 (通訊作者, SCI, impact factor:2.6, Ranking (Biotechnology & Applied Microbiology): 108/156 = 69.23 % (Q3), 5-Year IF: 2.3). Times cited: 16.
  35. Jui-Pin Wu, Mei-Hui Li, Jhih-Sheng Chen, Szu-Yao Chung, Hui-Ling Lee*, “Disturbances to neurotransmitter levels and their metabolic enzyme activity in a freshwater planarian exposed to cadmium”, NeuroToxicology 2015, 47, 72-81, DOI: 10.1016/j.neuro.2015.01.003 (通訊作者, SCI, impact factor: 3.4, Ranking (Toxicology): 34/94 = 36.17 % (Q2), 5-Year IF: 3.8). Times cited: 19.
  36. Wen-Chieh Chiang, Chao-Yu Chen, Ting-Chen Lee, Hui-Ling Lee*, Yu-Wen Lin, “Fast and simple screening for the simultaneous analysis of seven metabolites derived from five volatile organic compounds in human urine using on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry”, Talanta 2015, 132, 469-478, DOI: 10.1016/j.talanta.2014.09.029 (通訊作者, SCI, impact factor: 6.1, Ranking (Chemistry, Analytical): 9/86 = 10.47 % (Q1), 5-Year IF: 5.4). Times cited: 23.
  37. Kao-Lu Pan, Wei-Jan Huang, Ming-Hua Hsu, Hui-Ling Lee, Huei-Ju Liu, Chia-Wei Cheng, Ming-Hsien Tsai, Mei-Ya Shen, Pinpin Lin,“ Identification of trans,trans-2,4-decadienal metabolites in mouse and human cells using liquid chromatography−Mass Spectrometry”, Res. Toxicol 2014, 27, 1707−1719. DOI: 10.1021/tx500199b (SCI, impact factor: 4.1, Ranking (Toxicology): 25/94 = 26.59 % (Q2), 5-Year IF: 3.9). Times cited: 8.
  38. Jui-Pin Wu, Hui-Ling Lee, Mei-Hui Li, “Cadmium Neurotoxicity to a Freshwater Planarian”, Arch Environ Contam Toxicol, 2014, 67, 639-650, DOI: 10.1007/s00244-014-0056-0 (SCI, impact factor: 4, Ranking (Environmental Science): 109/274 = 39.78 % (Q3), 5-Year IF: 3.6). Times cited: 13
  39. Pinpin Lin, Hui-Ling Lee*, H.I. Cheng, C.Y. Chen, M.H. Tsai, H.J. Liu, “Metabolomic profiling of mice urine and serum associated with trans-trans 2, 4-decadienal induced lung lesions by liquid chromatography-mass spectrometry”. Analytical and Bioanalytical Chemistry 2014, 406, 4287–4297, DOI: 10.1007/s00216-014-7681-3 (通訊作者, SCI, impact factor: 4.3, Ranking (Chemistry, Analytical): 20/86 = 23.26% (Q1), 5-Year IF: 4). Times cited: 8.
  40. Chien-Cheng Jung, Hsiu-Hao Liang, Hui-Ling Lee, Nai-Yun Hsu, Huey-Jen Su,“ Allostatic load model associated with indoor environmental quality and sick building syndrome among office workers”, PLOS ONE 2014, 9, 4, DOI: 10.1371/journal.pone.0095791 (SCI, impact factor: 3.7, Ranking (Multidisciplinary sciences): 26/73 = 35.61 % (Q2), 5-Year IF: 3.8). Times cited: 21.
  41. Hui-Yi Liao, Yu-Teh Chung, Ching-Huang Lai, Shu-Li Wang, Hung-Che Chiang, Lih-Ann Li, Tsui-Chun Tsou, Wan-Fen Li, Hui-Ling Lee, Wei-Te Wu, Ming-Hsiu Lin, Jin-Huei Hsu, Jiune-Jye Ho, Chiou-Jong Chen, Tung-Sheng Shih, Chin-Chi Lin, Saou-Hsing Liou, “Six-month follow-up study of health markers of nanomaterials among workers handling engineered nanomaterials“, Nanotoxicology 2013, 8, 1–11, DOI: 10.3109/17435390.2013.858793, (SCI, impact factor: 5, Ranking (Toxicology): 14/94 = 14.89 % (Q1), 5-Year IF: 5.2). Times cited: 77.
  42. Chien-Yu Lin, Hui-Ling Lee, Yu-Chuan Chen, Guang-Wen Lien, Lain-Yu Line, “Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults” Journal of Hazardous Materials, 2013, 261, 372–377, DOI: 10.1016/j.jhazmat.2013.06.069 (SCI, impact factor: 13.6, Ranking (Environme ntal Science): 10/274 = 3.65 % (Q1), 5-Year IF: 12.7) Times cited: 25.
  43. Chi-Jung Chung, Yeong-Shiau Pu, Horng-Sheng Shiue, Hui-Ling Lee, Pinpin Lin Hsiu-Yuan Yang, Chien-Tien Su, Yu-Mei Hsueh, “4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma”, Toxicology Letters 2013, 216, 16–22, DOI: 10.1016/j.toxlet.2012.11.002 (SCI, impact factor: 3.5 Ranking (Toxicology): 33/94 = 35.10 % (Q2), 5-Year IF: 3.8). Times cited: 9.
  44. Chia-Chang Wu, Chien-Tien Su, Hui-Ling Lee, Chi-Jung Chung, Chao-Yuan Huang, Yeong-Shiau Pu, Pinpin Lin and Yu-Mei Hsueh,”Joint effect of arsenic methylation profile and NNK metabolites on urothelial carcinoma”, The Journal of Urology 2012, 188, 1701-1705, DOI: 10.1016/j.juro.2012.07.025 (SCI, impact factor: 6.6, Ranking (Urology & Nephrology): 9/88 = 10.23 % (Q1), 5-Year IF:6.2). Times cited: 4.
  45. Chien-Kai Wang, Hui-Ling Lee, Han Chang, Ming-Hsien Tsai, Yu-Chun Kuo and Pinpin Lin*, ”Enhancement between environmental tobacco smoke and arsenic on emphysema-like lesions in mice”, Journal of Hazardous Materials 2012, 221-222, 256-263, DOI: 10.1016/j.jhazmat.2012.04.042 (SCI, impact factor: 13.6, Ranking (Environmental Science): 10/274 = 3.65 % (Q1), 5-Year IF: 12.7). Times cited: 9.
  46. Saou-Hsing Liou, Tsui-Chun Tsou, Shu-Li Wang, Lih-Ann Li, Hung-Che Chiang, Wen-Fen Li, Pin-Pin Lin, Ching-Huang Lai, Hui-Ling Lee, Jin-Hue Hsu, Chiou-Rong Chen, Tung-Sheng Shih, Hui-Yi Liao and Yu-Teh Chung, ”Epidemiological study of health hazards among workers handling engineered nanomaterials”, Journal of Nanoparticle Research 2012, 14, 878–893, DOI: 10.1007/s11051-012-0878-5 (SCI, impact factor: 5, Ranking (Chemistry, Multidisciplinary): 106/178 = 59.55 % (Q3), 5-Year IF: 2.3). Times cited: 56.
  47. Jui-Pin Wu, Mei-Hui Li, Jhih-Sheng Chen and Hui‑Ling Lee*,”In vivo and in vitro metabolism of tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK),by the freshwater planarian, Dugesia japonica”, Chemosphere 2012, 87, 1341-1347, DOI: 10.1016/j.ch emosphere.2012.02.024 (通訊作者, SCI, impact factor: 8, Ranking (Environmental Sciences): 30/274 = 10.95 % (Q1), 5-Year IF: 8.3). Times cited: 8.
  48. Jein-Wen Chen, Shu-Li Wang, Dannis Paul Hsientang Hsieh, His-Hsien Yang, and Hui‑Ling Lee*, “Carcinogenic potencies of polycyclic aromatic hydrocarbons for back-door neighbors of restaurants with cooking emissions”, Science of the Total Environment 2012, 417-418, 68-75, DOI: 10.1016/j.scitotenv.2011.12.012 (通訊作者, SCI, impact factor: 9.8, Ranking (Environmental Sciences): 26/274 = 9.49 % (Q1), 5-Year IF: 9.6). Times cited: 94.
  49. Hung-Che Chiang , Yung-Kai Huang, Pei-Fen Chen , Chia-Chi Chang , Chien-Jen Wang, Pinpin Lin* and Hui-Ling Lee* , “4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydrox y-2′-deoxyguanosine in humans after exposure to environmental tobacco smoke”, Science of the Total Environment 2012, 414, 134-139, DOI: 10.1016/j.scitotenv.2011.12.012 (通訊作者, SCI, impact factor: 9.8, Ranking (Environmental Sciences): 26/274 = 9.49 % (Q1), 5-Year IF: 9.6). Times cited: 15.
  50. L. Su, D.W. Yuan, L.L. Chiang, Hui-Ling Lee, K.H. Chen, D. Wang, “Inducible cyclooxygenase expression mediating hypoxia/reoxygenation–induced pulmonary vasoconstriction is attenuated by a cyclooxygenase inhibitor in rats”, Transplantation Proceedings 2012, 44, 929-932, DOI: 10.1016/j.transpro ceed.2012.03.005 (SCI, impact factor: 0.9, Ranking (Surgery): 186/212 = 87.74% (Q3), 5-Year IF: 0.9). Times cited: 4.
  51. Chien-Jen Wang, Ning-Hsiang Yang, Chia-Chi Chang, Saou-Hsing Liou, Hui-Ling Lee*, “Rapid and simple one-step membrane extraction for the determination of 8-hydroxy-2’-deoxyguanosine in human plasma by a combination of on-line solid phase extraction and LC–MS/MS”, Journal of Chromatography B 2011, 879, 3538-3543, DOI: 10.1016/j.jchromb.2011.09.038 (通訊作者, SCI, impact factor: 3, Ranking (Chemistry, Analytical): 40/86 = 46.51 % (Q2), 5-Year IF: 2.9). Times cited: 32.
  52. Huai-Chih Chiang, Chin-Ying Wang, Hui-Ling Lee, Tsui-Chun Tsou, “Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamin o)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation—A mammalian cell-based mutagenesis approach”, Toxicology and Applied Pharmacology 2011, 253, 145-152, DOI: 10.1016/j.taap.2011.03.022 (SCI, impact factor: 3.8, Ranking (Toxicology): 24/94 = 30.85 % (Q2), 5-Year IF: 4). Times cited: 34.
  53. Chi-Jung Chung, Hui-Ling Lee, Hsiu-Yuan Yang, Pinpin Lin, Yeong-Shiau Pu, Horng-Sheng Shiue, Chien-Tien Su, Yu-Mei Hsueh, “Low ratio of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol-glucuronides (NNAL-Gluc)/free NNAL increases urothelial carcinoma risk”, Science of the Total Environment 2011, 409, 1638-1642, DOI: 10.1016/j.scitotenv.2011.01.046 (SCI, impact factor: 9.8, Ranking (Environmental Sciences): 26/274 = 9.48 % (Q1), 5-Year IF: 9.6). Times cited: 10.
  54. Hui-Ling Lee, Dennis P. H. Hsieh, Lih-Ann Li,“ Polycyclic aromatic hydrocarbons in cigarette sidestream smoke particulates from a Taiwanese brand and their carcinogenic relevance”, Chemosphere 2011, 82, 477-482, DOI: 10.1016/j.chemosphere.2010.09.045 (SCI, impact factor: 8.8, Ranking (Environmental Sciences): 30/275 = 10.95 % (Q1), 5-Year IF: 8.3). Times cited: 29.
  55. Chien-Jen Wang , Ning-Hsiang Yang, Saou-Hsing Liou ,Hui-Ling Lee*, “Fast quantification of the exhaled breath condensate of oxidative stress 8-iso-prostaglandin F2α using on-line solid-phase extraction coupled with liquid chromatography/electrospray ionization mass spectrometry”, Talanta 2010, 82, 1434-1438, DOI: 10.1016/j.talanta.2010.07.015 (通訊作者, SCI, impact factor: 1, Ranking (Chemistry, Analytical): 9/86 = 10.47 % (Q1), 5-Year IF: 5.4). Times cited: 15.
  56. Hsien-Yu Cheng, Show-Chuen Chen*, Hui-Ling Lee*, “Fast analysis of phenolic acids by microchip capillary electrophoresis with serpentine channel and end wrapped electrode”, Journal of the Chinese Chemical Society 2010, 57, 371-377, DOI: 10.1002/jccs.201000055 (通訊作者, SCI, impact factor: 8, Ranking (Chemistry, Multidisciplinary): 123/178 = 69.10 % (Q3), 5-Year IF: 1.6). Times cited: 4.
  57. Shun-ChiehYoung, LouisW.Chang, Hui-Ling Lee, Lung-Hung Tsai, Yin-Chang Liu, and Pinpin Lin*, “DNA damage induced by trans, trans-2,4-decadienal (tt-DDE), a component of cooking oil fume, in human bronchial epithelial cells”, Environmental and Molecular Mutagenesis 2010, 51, 315-321, DOI: 10.1002/em.20550 (SCI, impact factor: 2.8, Ranking (Toxicology): 57/94 = 60.64 % (Q3), 5-Year IF: 3.7). Times cited: 30.
  58. Hui-Ling Lee, Yu-Mei Hsueh, Chi-Jung Chung, Louis W. Chang, Dennis Paul Hsientang Hsieh, Pinpin Lin*, “Correlation between the Urine Profile of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Metabolites and N7-Methylguanine in Urothelial Carcinoma Patients”, Cancer Epidemiology, Biomarker & Prevention 2008, 17, 3390-3395, DOI:1158/1055-9965.EPI-08-0761 (SCI, impact factor: 3.8, Ranking (Public, Environmental & Occupational Health): 80/207 = 38.65 % (Q2), 5-Year IF: 4.8). Times cited: 17.
  59. Hui-Ling Lee, Louis W. Chang, Jui-Pin Wu, Yune-Fang Ueng, Ming-Hsien Tsai, Dennis Paul Hsientang. Hsieh, Pinpin Lin, “Enhancement of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridy l)-1-butanone (NNK) as mechanistic base for increased cigarette smoke carcinogenic risk by arsenic”, Toxicology Applied and Pharmacology 2008, 227, 108-114, DOI: 10.1093/carcin/12.12.2277 (SCI, impact factor: 3.8, Ranking (Toxicology): 29/94 = 30.85 % (Q2), 5-Year IF: 4). Times cited: 12.
  60. Hui-Ling Lee, Chiying Wang, Susana Lin, Dennis Paul Hsientang Hsieh*, (2007) “Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites” Talanta 2007, 73, 76-80, DOI: 10.1016/j.talanta.2007.03.001 (SCI, impact factor: 1, Ranking (Chemistry, Analytical): 9/86 = 10.47 % (Q1), 5-Year IF: 5.4). Times cited: 34.
  61. Hsi-Hsien Yang, Shu-Mei Chien, Hui-Ling Lee, Mu-Rong Chao, Hong-Wei Luo, Hsien-Tang Hsieh, Wen-Jhy Lee, (2007) “Emission of trans,trans-2,4–decadienal from restaurant discharges to the atmosphere” Atmospheric Environment 2007, 41 5327-5332, DOI: 10.1016/j.atmosenv.2007.02.031 (SCI, impact factor: 5, Ranking (Environmental sciences): 78/274 = 28.46 % (Q2), 5-Year IF: 5.2). Times cited: 20.

研討會論文

  1. Wei-Ting Jung, Pinpin Lin,* Hui-Ling Lee*, “Particulate matter treatment induced metabolomic profiling change in mice model by liquid chromatography mass spectrometry” ,2023第十九屆台灣質譜年會，臺灣，中興大學(台中金典酒店)，2022年07月01日至07月06日
  2. Hao-En Huang, Wei-Ting Jung, Hui-Ling Lee *, “A modified QuEChERS coupled to hydroxyapatite-based extraction procedure for six steroid compounds determination by LC-MS/MS “, 51st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2023) June 18-22, 2023德國,杜塞道夫Düsseldorf
  3. Yi-Hsuan Hsieh, Hui-Ling Lee*, “Dispersive solid phase adsorbent based on vinylene-based covalent organic framework for determination of beta-agonist residue in meat samples by UHPLC–MS/MS”, 第二十八屆分析化學技術交流研討會，臺灣，成功大學，2023年05月13日，榮獲口頭報告論文獎
  4. Wei-Ting Jung, Hui-Ling Lee* , “Cu–S MOF microrods as novel sorbent using UHPLC–MS/MS to determine fluoroquinolones”, 第二十八屆分析化學技術交流研討會，臺灣，成功大學，2023年05月13日
  5. Hsun-Ming Wang, Hui-Ling Lee*, “Simultaneous determination of phthalate monoesters and eicosanoids in biological samples by UHPLC-MS/MS”, 第二十八屆分析化學技術交流研討會，臺灣，成功大學，2023年05月13日
  6. Yi-Hsuan Hsieh, Hui-Ling Lee*, “A novel vinylene-based covalent organic framework applied to pretreatment technique coupling with ultra-high performance liquid chromatography tandem mass spectrometry on determination of beta-agonist in meat samples”, 2023中國化學會年會，臺灣，高雄大學，2023年03月11日至03月12日，榮獲優秀壁報論文獎
  7. Antonia Trisha Zac R, Hui-Ling Lee*, “Rapid synthesis of a bimetallic Fe/Cu–MOF based nanoenzyme for detection of caffeic acid”, 2023中國化學會年會，臺灣，高雄大學，2023年03月11日至03月12日
  8. Hsun-Ming Wang, Hui-Ling Lee* ,“A simple extraction method for the simultaneous determination of phthalic acid monoesters and eicosanoids in human plasma by UHPLC-MS/MS”, 2023中國化學會年會，臺灣，高雄大學，2023年03月11日至03月12日
  9. Wei-Ting Jung, Chien-Yu Lin, Hui-Ling Lee,* Copper Based Metal Organic Framework as Novel Dispersive Solid Phase Extraction Sorbent for the Analysis of Fluoroquinolones with UHPLC MS/MS”2022第十八屆台灣質譜年會，臺灣，師範大學，2022年08月16日至08月18日
  10. Yen-Jung Kuo, Hui-Ling Lee * , “Amino functionalized metal–organic framework for magnetic solid phase extraction combined with HPLC–MS/MS for the detection of parabens”, 2022世界質譜年會，荷蘭馬垂斯克，2022年8月27日至9月02日
  11. Yen-Jung Kuo, Hui-Ling Lee*, “A metal–organic framework of type MIL-101-SO3H for DSPE and UHPLC–MS/MS analysis of fluoroquinolones” 2022第二十七屆分析化學技術交流研討會，臺灣，高雄中山大學，2022年06月11日至06月12日
  12. Bing-Chen Wu, Hui-Ling Lee*, “Integrated V-COF-1/carbon nanotube cmposite modified electrode as a novel electrochemical sensor for sunset yellow and tartrazine detection” 2022第二十七屆分析化學技術交流研討會，臺灣，高雄中山大學，2022年06月11日至06月12日
  13. Yi-Hsuan Hsieh, Wei-Ting Jung, Hui-Ling Lee* “A comparison of the effectiveness of polydopamine modified material based magnetic SPE and FaPEx on the determination of beta agonist with HPLC–MS/MS” 2022中國化學會年會，臺灣，師範大學，2022年03月12日至03月13日，榮獲優秀壁報論文獎
  14. Yen-Jung Kuo, Hui-Ling Lee * “A metal–organic framework of type MIL-101(Cr) sorbent for DSPE of fluoroquinolones by UHPLC-MS/MS” 2022中國化學會年會，臺灣，師範大學，2022年03月12日至03月13日
  15. Wei-Ting Jung, Hui-Ling Lee,*”Targeted of tryptophan profiling induced by particulate matter treatment in mice feces and urine by UHPLC-MS/MS” 2021中國化學會年會，臺灣，中央大學，2021年03月13日至03月14日
  16. Wei-Ting Jung, Chien-Yu Lin, Hui-Ling Lee,* “Determination of urinary levels of 1,3-butadiene metabolites, oxidative stress products by HPLC-MS/MS and the association between cardiovascular risk factors, microparticles in adolescents” 2020第十七屆台灣質譜年會，臺灣，嘉義大學，2020年09月01日至09月03日
  17. Wei-Ting Jung, Hui Ling Lee*“Novel nano magnetic composites and magnetic metal-organic frameworks for the magnetic solid-phase extraction of steroids and β-agonists with LC-MS/MS” 8th Asia-Oceania Mass Spectrometry Conference (AOMSC) 2020. 澳門2020年1月05日至1月07日
  18. Wei-Ting Jung, Hui Ling Lee* “Measurement of Urinary 8- OHdG and DNA Hypomethylation by HPLC MS/MS in a Case Control Study of Urothelial Carcinoma” 2019年中國化學會年會暨18th ACC(第18屆亞洲化學大會暨第20屆亞洲化學學會聯盟會員大會)，臺灣，台灣大學，2019年12月08日至12月12日
  19. Jen-Han Wu, Hui-Ling Lee* “Determination of sunset yellow and tartrazine in drinks using reduced graphene oxide and NiBTC frameworks modified screen-printed carbon electrodes” 2019中國化學會年會，臺灣，台灣大學，2019年12月08日至12月12日
  20. Wei-Ting Jung, Yao-Wei Zhuang, Hui Ling Lee* “Development of magnetic dispersive solid phase extraction for the sensitive determination of azobenzene dye by HPLC MS/MS’’ 第49屆高效能液相層析分離相關技術之國際研討會 (HPLC 2019)，日本京都2019年12月01日至12月05日
  21. Wei-Ting Jung, Chao-Yu Chen, Hui-Ling Lee* “Simultaneous and fast quantification of volatile organic compounds metabolites in human urine by on-line SPE LC-MS/MS: correlation with 8-hydroxydeoxyguanosine and tobacco exposure biomarkers NNAL” 2019第十六屆台灣質譜年會，臺灣，台中中興大學，2019年07月03日至07月05日
  22. 郭進平，李慧玲* ”奈米碳黑/碳量子點結合金屬有機骨架配位化合物MIL-101(Cr)修飾電極偵測咖啡酸”2019第二十五屆分析化學技術交流研討會，臺灣，台中東海大學，2019年05月25日
  23. 溫挺傑，李慧玲* “線上自動濃縮固相萃取結合液相層析串聯質譜儀偵測人體血漿中全氟碳化合物與異構物的方法開發與應用”2019第二十五屆分析化學技術交流研討會，臺灣，台中東海大學，2019年05月25日
  24. Chih-Yuan Kang, Wei-Ting Jung Hui-Ling Lee* “Magnetic dispersive solid phase extraction based on a novel adsorbent for the detection of phenolic acids compounds in fruit wine by HPLC-MS/MS” 第48屆高效能液相層析分離相關技術之國際研討會 (HPLC 2019)，義大利米蘭2019年06月16日至06月20日
  25. Hui-Ling Lee*, Chien-Yu Lin “Positive association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress biomarker 8-hydroxydeoxyguanosine in adolescents and young adults by liquid chromatography-tandem mass spectrometry”2018中國化學會年會，臺灣，中山大學，2018年12月08日至12月09日
  26. 余孟哲，榮偉廷，李慧玲* “羧酸化多壁奈米碳管結合有機金屬骨架化合物 MIL-101(Cr)修飾網版印刷碳電極偵測 2-羥基雌二醇和 4-羥基雌二醇” 2018中國化學會年會，臺灣，中山大學，2018年12月08日至12月09日
  27. Saou-Hsing Liou, Chao-Yu Chen, Cheng-Yen Tsai, Hui-Ling Lee* “Determination of global DNA methylation and oxidation of DNA and lipid biomarkers in metal oxide nanomaterial-handling workers by liquid chromatography-tandem mass spectrometry” 2018第二十二屆世界質譜年會，義大利佛羅倫斯，2018年8月25日至8月31日
  28. Cheng-Yen Tsai, Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee* “Metabolic profiling of amino acid and arachidonic acid pathway changes of zinc oxide nanoparticle-induce acute pulmonary inflammation in mice serum using LC-MS/MS” 2018第十五屆台灣質譜學會年會暨第七屆世界華人質譜研討會，臺灣，台北中央研究院，2018年07月18日至07月20日
  29. Ren-Shang Shen, Hui-Ling Lee* ”以聚殼醣結合有機金屬骨架材料MIL-101修飾電極偵測對乙醯氨基酚” 2018第二十四屆分析化學技術交流研討會，臺灣，基隆海洋大學，2018年05月19日
  30. Chih-Yuan Kang, Hui-Ling Lee * ” Magnetic Dispersive Solid-Phase Extraction Based on a Novel Adsorbent for the Detection of Eleven Phenolic Acids Compounds by HPLC-MS/MS” 2018第二十四屆分析化學技術交流研討會，臺灣，基隆海洋大學，2018年05月19日
  31. Cheng-Yen Tsai, Wei-Ting Jung, Hui-Ling Lee* “A Calcium (II)-based metal-organic framework material for the dispersive solid-phase extraction of tryptophan metabolites for biological samples with LC-MS/MS” 66th美國質譜年會, 2018年6月03日至6月07日, 美國聖地牙哥
  32. Hui-Ling Lee*, Cheng-Yen Tsai, Wei-Ting Jung, Pinpin Lin,“Targeted lipidomics and amino acid profiling of acute arsenic exposure in mice using liquid chromatography-mass spectrometry” 6th美國質譜年會, 2018年6月03日至6月07日, 美國聖地牙哥
  33. Jhih-Sheng Chen, Hui-Ling Lee* “Electrochemical sensing of five estrogens and their metabolites based on multi-walled carbon nanotubes/poly-glutamic acid modified screen-printed carbon electrode”2017中國化學會年會，臺灣，嘉義大學，2017年12月01日至12月02日
  34. Cheng-Yen Tsai，Hui-Ling Lee* “Polymer monolith as the sorbent for in-tube solid-phase microextraction combined with UPLC/DAD for analysis of tryptophan metabolites” 2017中國化學會年會，臺灣，嘉義大學，2017年12月01日至12月02日
  35. Chao-Yu Chen, Cheng-Yen Tsai, Wei-Ting Jung and Hui-Ling Lee*, ”Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles by liquid chromatography-tandem mass spectrometry” 2017 年第十四屆質譜學會年會，臺灣，台中中興大學，2017年06月28日至06月30日
  36. Chao-Yu Chen, Hui-Ling Lee*, Yu -Wen Lin “Simultaneous, fast and simple quantification of oxidative damage biomarker and cotinine in human urine by on-line SPE LC-MS/MS: correlation with tobacco exposure biomarkers NNAL” 第45屆高效能液相層析分離相關技術之國際研討會 (HPLC 2017)，捷克布拉格2017年06月18日至06月22日
  37. Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee “Targeted lipidomics profiling of acute arsenic exposure in mice serum by on-line solid-phase extraction stable-isotope dilution liquid chromatography–tandem mass spectrometry” 第45屆高效能液相層析分離相關技術之國際研討會 (HPLC 2017)，捷克布拉格2017年06月18日至06月22日
  38. Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee,“Targeted lipidomics profiling of acute arsenic exposure in mice serum by on-line solid-phase extraction stable-isotope dilution liquid chromatography–tandem mass spectrometry” 2017第二十三屆分析化學技術交流研討會，臺灣，高雄中山大學，2017年05月27日
  39. 莊曜瑋,李慧玲“以磁性固相萃取法結合液相層析二極陣列偵測器與液相層析串聯質譜儀快速檢測偶氮苯類染料”2017第二十三屆分析化學技術交流研討會，臺灣，高雄中山大學，2017年05月27日
  40. Pinpin Lin, Chao-Yu, Chen, Ming-Hsien Tsai, Hui-Ling Lee*, ” The serum eicosanoids profiles of early epidermal growth factor receptor mutation by LC-MS” , 2016中國化學會年會，臺灣，台中中興大學，2016年12月03日至12月04日
  41. Saou-Hsing Liou1, Hui-Yi Liao1,Jhih-Sheng Chen2, Chien-Jen Wang1,Hui-Ling Lee2* “Determination of association oxidative stress biomarker in metal oxides nanomaterial handling workers using on-line solid phase LC-MS/MS” 2016第二十一屆世界質譜年會，加拿大多倫多，2016年8月20日至8月26日
  42. Chao-Yu, Chen, Hui-Ling, Lee*, “Metabolic profiling of amino acid and arachidonic acid pathway changes of Arsenic exposure in mice serum and urine” , 2016第十三屆台灣質譜年會，臺灣，高雄中山大學，2016年6月27日至6月29日
  43. Metabolomics approach for mice serum associated with epidermal growth factor receptor and BaP-induced mouse lung tumorigenesis using liquid chromatography-mass spectrometry, 李慧玲,陳昭宇, 林嬪嬪, 64th美國質譜年會, 2016年6月04日至6月09日, 美國聖安東尼奧
  44. Yi-An Chen , Hui-Ling Lee “Development of a QuEChERS-based extraction method for the determination of six steroid compounds in human urine by LC-MS/MS” 2016第二十二屆分析化學技術交流研討會，臺灣，高雄醫學大學藥學院，2016年05月21日
  45. Yu-Ting Jhou, Hui-Ling Lee “Simultaneous, rapid and sensitive quantification of volatile organic compounds metabolites in urine by on-line solid-phase extraction LC-MS/MS “2016第二十二屆分析化學技術交流研討會，臺灣，高雄醫學大學藥學院，2016年05月21日
  46. Chao-Yu Chen, Yu-Ting Jhou, Hui-Ling Lee*,”Targeted Metabolic Profiling of Arsenic Induced Oxidative Stress in Mice Serum and Urine by Liquid Chromatography-Mass Spectrometry” , 2015中國化學會年會，臺灣，花蓮東華大學，2015年12月05日至12月06日
  47. Jhih-Sheng Chen, Ren-Siang Shen, Reevan Pais, Hui-Ling Lee*,“Simultaneous electrochemical determination of 4-hydroxyestradiol and 17β-estradiol by using poly (tryptophan)/functionalized multi-walled carbon nanotubes modified screen-printed carbon electrode” , 2015中國化學會年會，臺灣，花蓮東華大學，2015年12月05日至12月06日
  48. Yu-Ting Jhou, Hui-Ling Lee, “Development of an analytical method for the targeted screening by on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry for quantitative analysis of volatile organic compounds metabolites in urine”, 2015第十二屆台灣質譜年會，臺灣，交通大學，2015年07月13日至07月15日
  49. Saou-Hsing Liou1, Yu-Cheng Chen2, Jhih-Sheng Chen2, Chao-Yu Chen2, Hui-Ling Lee2 “Determination of association oxidative stress biomarker in various body fluids by LC-MS/MS” 2015 APCE (第15屆亞太地區微分離及分析研討會)，成功大學，2015年11月15日至11月18日
  50. Pinpin Lin 1, Chao-Yu Chen2, Jhih-Sheng Chen2, Hui-Ling Lee2, “Metabolomic profiling of mice serum associated with BaP-induced mouse lung tumorigenesis by liquid chromatography-mass spectrometry” 2015 APCE (第15屆亞太地區微分離及分析研討會)，成功大學，2015年11月15日至11月18日
  51. Chao-Yu Chen , Hui-Ling Lee*, “Fast and simple screening for the simultaneous analysis of seven metabolites derived from five volatile organic compounds in human urine using on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry”, 2015, 31st International Conference of the Society for Environmental Geo Chemisty and Health, June 22-26, 2015 (Bratislava – Slovak Republic) 斯洛伐克,布拉提斯拉瓦
  52. 陳昭宇, 蔡明憲, 林嬪嬪, 李慧玲, “以線上自動濃縮固相萃取連結液相層析串聯質譜儀偵測類花生四烯酸之方法開發與不同生物體液應用”2015第二十一屆分析化學技術交流研討會，臺灣，嘉義大學化學系，2015年05月30日至05月31日
  53. 陳昭宇, 蔡明憲, 林嬪嬪, 李慧玲“以線上自動濃縮固相萃取連結液相層析串聯質譜儀偵測血清中類花生四烯酸之方法開發與應用” 2014中國化學會年會，臺灣，新竹工研院，2014年11月21日至11月23日
  54. 李懿, 陳志昇,李慧玲” 網版印刷碳電極結合奈米複合碳材偵測雙酚A和對苯二酚” 2014中國化學會年會，臺灣，新竹工研院，2014年11月21日至11月23日
  55. Chao-Yu Chen, Pinpin Lin, Hui-Ling Lee*, Hao-I Cheng, Ming-Hsien Tsai, Huei-Ju Liu, “Metabolomic study of trans-trans 2, 4-decadienal induced lung lesions in mice by liquid chromatography-mass spectrometry” 2014第二十屆世界質譜年會，瑞士,日內瓦 8月24~29日
  56. 張雅婷, 李慧玲 ”以液相層析質譜法探討組蛋白去乙醯酶抑制劑YCW-3之小鼠標靶代謝物特徵性之研究” ，2014第十一屆台灣質譜年會，臺灣，中興大學，2014年06月29日至07月01日
  57. Chao-Yu Chen, Pinpin Lin, Hui-Ling Lee*, Hao-I Cheng, Ming-Hsien Tsai, Huei-Ju Liu, “Metabolomic profiling of mice serum associated with trans-trans 2, 4-decadienal, a component of cooking oil fumes induced lung lesions by LC-MS” ，2014第十屆代謝質體學國際研討會，日本山形縣鶴岡市6月23~26日
  58. 李懿, 李慧玲 ”網版印刷碳電極結合奈米複合碳材同時偵測雙酚A、8-羥基-2′-脫氧鳥苷、對苯二酚之方法開發及應用” ，2014第二十屆分析化學技術交流研討會，臺灣，中原大學化學系，2014年05月31日至06月01日
  59. Wen-Chieh Chiang, Hui-Ling Lee, Fast determination and quantification of urinary VOCs metabolites by using stable isotope dilution on-line solid-phase extraction coupled with liquid chromatography-electrospray ionization mass spectrometry，2014第二十屆分析化學技術交流研討會，臺灣，中原大學化學系，2014年05月31日至06月01日
  60. Chia-Xin Lien, Chao-Yu Chen, Jhih-Sheng Chen , Ming-Hsien Tsai, Pinpin Lin, Hui-Ling Lee,* “Metabolomic Profiling of Mice Urine with Cigarette Smoke and Arsenic by Liquid Chromatography-Mass Spectrometry” ，2013中國化學年會，臺灣，暨南大學化學系11月23~24日
  61. 鐘思堯, 李慧玲” 以液相層析技術結合奈米級材料修飾電極之電化學偵測器於神經傳導物及其代謝物之方法開發與應用” ，2013中國化學年會，臺灣，暨南大學化學系11月23~24日
  62. Jui-Pin Wu, Mei-Hui Li, Hui-Ling Lee, “Comparative toxicities of Cd, Cu, and Zn to freshwater planarians with comparisons to other invertebrates” 4th International Symposium on Metallomics, Oviedo,Spain, 8-11 July 2013
  63. Chia-Xin Lien, Chao-Yu Chen, Jhih-Sheng Chen , Ming-Hsien Tsai, Pinpin Lin, Hui-Ling Lee,* “Urinary Metabolomic Study on Biochemical Profile by Cigarette Smoke and Arsenic Exposure in Mice : LC-MS based Analysis” 第四屆亞洲與大洋洲質譜會議暨第十屆台灣質譜年會，臺灣，中研院，2013年07月10~12日
  64. 陳志昇, 李慧玲 “奈米碳黑環糊精修飾電極於雌激素化合物偵測之應用” ，2013第十九屆分析化學技術交流研討會，臺灣，師範大學化學系，2013年05月25日
  65. 陳昭宇, 李慧玲 “Determination of Isoprostanes in Human Urines Using Novel Nano Hap as Sorbent by LC-MS/MS” ，2013第十九屆分析化學技術交流研討會，臺灣，師範大學化學系，2013年05月25日
  66. Determination of isoprostanes in human urines using novel nano-scale carbon powder- hydroxyapatite as solid phase extraction sorbent by LC-MS/MS李慧玲,陳昭宇,王建仁, 劉紹興,60th美國質譜年會, 五月, 2012, 加拿大溫哥華
  67. 陳志昇, 李慧玲 “電化學修飾電極技術於偵測雌激素化合物之方法開發” ，2012第十八屆分析化學技術交流研討會，臺灣，國立中山大學化學系，2012年05月26日
  68. Sensitive determination of isoprostanes in human urines using novel nano-material as solid phase extraction sorbent by LC-MS/MS, 陳昭宇,王建仁, ,李慧玲, 2012台灣質譜年會, 六月, 2012, 台南
  69. 以液相層析串聯質譜儀(LC-MS/MS)來探討暴露奈米微粒作業人員氧化壓力指標物8-OHdG與全面性甲基化的特徵性研究, 陳玉承,王建仁, ,李慧玲, 2012中國化學年會, 十二月, 2012, 台南
  70. 陳志昇, 李慧玲 “奈米級碳黑修飾電極於雌激素化合物之方法開發與應用”， 2011中國化學年會，臺灣，清大化學系，2011年12月03日
  71. 程皓頤, 林嬪嬪, 李慧玲 “以LC-MS應用於小鼠吸入二手香菸對肺部沖洗液之代謝質體學特徵性的研究”， 2011中國化學年會，臺灣，清大化學系，2011年12月03日
  72. 王建仁, 楊甯翔, 張佳琪, 劉紹興, 李慧玲 “Rapid and simple one-step membrane extraction for the determination of 8-hydroxy-2’-deoxyguanosine in human plasma by a combination of on-line solid phase extraction and LC-MS/MS” ，2011 台灣質譜年會，台北，臺灣，中研院，2011年07月10日
  73. 王千豪, 李慧玲 “微電泳晶片結合石墨烯修飾電極之方法開發與應用” ，2011第十七屆分析化學技術交流研討會，臺灣，中興大學化學系，2011年05月14日
  74. 連家興, 李慧玲“Using on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry for tobacco-specific nitrosamine metabolite analysis”，2010中國化學年會，臺灣，台大化學系，2010年12月04日
  75. 楊甯翔, 王建仁, 劉紹興, 李慧玲 “Fast quantification of the exhaled breath condensate and urine of oxidative Stress 8-iso-prostaglandin F2α using on-line solid-phase extraction coupled with liquid chromatography/electrospray ionization mass spectrometry”，2010中國化學年會，臺灣，台大化學系，2010年12月04日
  76. 連家興, 林嬪嬪, 李慧玲 “LC-MS/MS for investigating the DNA modifications by cigarette smoke exposure in mice”，2010 台灣質譜年會，高雄，臺灣，高雄醫學大學，2010年06月26日
  77. “Study of the oxidative stress marker profile by using on-line SPE/LC-MS/MS”，2010 台灣質譜年會，高雄，臺灣，高雄醫學大學，2010年06月27日
  78. 王建仁, 劉紹興, 李慧玲 “建立以快速、簡便的線上濃縮固相萃取連結液相層析串聯質譜儀(LC-MS/MS)來分析呼吸道檢體與尿中isoprostanes的代謝物” 台灣質譜學會, 六月, 2009
  79. Chiying Wang, Hui-Ling Lee, Kuen-Yuh Wu, Dennis Paul Hsientang Hsieh, “Liquid chromatography/tandem mass spectrometric method for the quantification of trans, trans-2,4-decadienal in restaurant kitchen” 56th ASMS Conference on Mass Spectrometry June 1 – June 5, 2008, Denver, Colorado.
  80. Jui-Pin Wu(吳瑞梹), Hui-Ling Lee(李慧玲), Ming-Hsien Tsai(蔡明憲), Louis W. Chang(張惠華), Pinpin Lin(林嬪嬪), “Arsenic increased metabolic activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mice” 第二十二屆生物醫學聯合學術會議優秀學術壁報論文獎, 台北 三月, 2008
  81. Hui-Ling Lee(李慧玲) *, Chiying Wang(王姿穎), Pinpin Lin(林嬪嬪), Louis W. Chang(張惠華), Jui-Pin Wu(吳瑞梹), Ming-Hsien Tsai(蔡明憲), Dennis Paul Hsientang Hsieh(謝顯堂) “Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/arsenic interaction”中國化學年會, 十二月, 2007
  82. Hui Ling Lee, Chiying Wang, Louis W Chang, Pin Pin Lin, Dennis P H Hsieh, “Effect of arsenic on the metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mice analyzed by LC-MS/MS” 55th ASMS Conference on Mass Spectrometry June 3 – June 7, 2007, Indianapolis, Indiana.
  83. Hui-Ling Lee(李慧玲), Chiying Wang(王姿穎), Hsi-Hsien Yang(楊錫賢), Dennis Paul Hsientang Hsieh(謝顯堂), “Liquid chromatography/tandem mass spectrometric method for the quantitation of trans, trans-2,4-decadienal in restaurant exhausts”中國化學年會, 十一月, 2006
  84. Hui Ling Lee, Chiying Wang, Dennis P H Hsieh, “Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of six the tobacco-specific nitrosamine metabolites” 54th ASMS Conference on Mass Spectrometry May 28 – June 1, 2006, Seattle, Washington.

專利或專書

  • 陳壽椿，尤進州，李慧玲，李坤隆，“化學晶片”,中國化學雜誌, 二月, 2001

環境介紹

我們的實驗室為 CH312 的學生提供了全面的學習，強調實踐操作，在電化學分析、層析方法和關鍵材料合成等方面獲得專業技能，培養直接應用於實際場景的實用技能。我們特別強調學生擁有積極負責的心態和必備的技能，包括效率、有效溝通、合作精神和積極進取的態度，以應對職場的變動挑戰。

實驗室融合了最新的技術與關注行業標準，特別注重對分析儀器的精通，尤其是層析技術。學生將學會運用和理解這些儀器的細微差異，為他們未來在研發、製藥、檢驗、工程和公共服務等領域的職業生涯打下堅實基礎。我們全面的實驗室學習打開了通往各種行業的大門，可以在研發部門、檢驗機構、製藥公司、工程職位和公共服務等領域就業。

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